Aims Suicide Attempt (SA) is common among individuals with mood disorders, and trait impulsivity is a strongly associated risk factor. However, findings on the relationship between trait impulsivity and SA vary widely. We hypothesized that impulsivity is associated with SA in patients with mood disorders (either MDD or BD), and we tested how diagnostic category and Subjective Social Status (SSS) may impact this relationship. Methods Participants with bipolar disorder (BD; types I and II) and...

CONCLUSIONS: Our findings support the presence of elevated brain age in BD and lithium's suggested neuroprotective profile and highlight the influence of the brain age model, MRI scanner, and other confounders on predictions.

CONCLUSIONS: The ASERT can be feasibly deployed to track mood and can help schedule follow-up assessments in BD longitudinal studies.

CONCLUSIONS: This study illustrates that DNA methylation is altered in individuals with bipolar disorder and a history of suicide attempts in regions known to harbor suicide-related variants.

CONCLUSIONS: In this small sample size study, differential methylation in ARHGEF38 was not associated with history of suicide attempt, failing to replicate findings from a related outcome, suicide death. However, we did provide evidence of SNP and DNA methylation interplay in this region. This highlights the relevance of considering genetics when interrogating epigenetic mechanisms.