CONCLUSIONS: Our findings support the presence of elevated Brain Age in BD, lithium's suggested neuroprotective profile, and highlight the influence of the Brain Age model, MRI scanner, and other confounders on predictions.

CONCLUSIONS: The ASERT can be feasibly deployed to track mood and can help schedule follow-up assessments in BD longitudinal studies.

CONCLUSIONS: This study illustrates that DNA methylation is altered in individuals with bipolar disorder and a history of suicide attempts in regions known to harbor suicide-related variants.

CONCLUSIONS: In this small sample size study, differential methylation in ARHGEF38 was not associated with history of suicide attempt, failing to replicate findings from a related outcome, suicide death. However, we did provide evidence of SNP and DNA methylation interplay in this region. This highlights the relevance of considering genetics when interrogating epigenetic mechanisms.

CONCLUSIONS: In this relatively small sample size study, differential methylation in ARHGEF38 was not associated with history of suicide attempt, failing to replicate findings from a related outcome, suicide death. However, we did provide evidence of SNP and DNA methylation interplay in this region. This highlights the potential relevance of considering genetics when interrogating epigenetic mechanisms.