Magnotta Bipolar Disorder
Investigating the Relationship Between DNA Methylation, Genetic Variation, and Suicide Attempt in Bipolar Disorder
Friday, June 6, 2025
CONCLUSIONS: This study illustrates that DNA methylation is altered in individuals with bipolar disorder and a history of suicide attempts in regions known to harbor suicide-related variants.
SNP-associated differential methylation in <em>ARHGEF38</em>: insights into genetic-epigenetic interactions
Friday, May 30, 2025
CONCLUSIONS: In this small sample size study, differential methylation in ARHGEF38 was not associated with history of suicide attempt, failing to replicate findings from a related outcome, suicide death. However, we did provide evidence of SNP and DNA methylation interplay in this region. This highlights the relevance of considering genetics when interrogating epigenetic mechanisms.
SNP-Associated Differential Methylation in <em>ARHGEF38:</em> Insights into Genetic-Epigenetic Interactions
Monday, March 17, 2025
CONCLUSIONS: In this relatively small sample size study, differential methylation in ARHGEF38 was not associated with history of suicide attempt, failing to replicate findings from a related outcome, suicide death. However, we did provide evidence of SNP and DNA methylation interplay in this region. This highlights the potential relevance of considering genetics when interrogating epigenetic mechanisms.
Characteristics of people with bipolar disorder I with and without auditory verbal hallucinations
Friday, February 14, 2025
CONCLUSION: Our findings suggest that people with BD-I with AVHs exhibit more severe psychotic features and manic symptoms compared to those without. This might be associated with more socioeconomic hardship. More in-depth characterization of people with BD-I with/without AVHs is needed to fully understand this subgroup's unique challenges and needs.
Immune dysregulation in bipolar disorder
Thursday, January 16, 2025
BACKGROUND: Bipolar disorder is a debilitating mood disorder associated with a high risk of suicide and characterized by immune dysregulation. In this study, we used a multi-faceted approach to better distinguish the pattern of dysregulation of immune profiles in individuals with BD.
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